At least 2 vehicles have been involved in the crash on the A3021 Whippingham Road.
Fire appliances from Newport and East Cowes have been mobilised to the incident alongside paramedics from the Isle of Wight Ambulance Service.
Emergency services were called to the scene at 18:10.
Traffic is heavy between Racecourse roundabout and East Cowes with a road closure expected. Motorists should avoid the area.
UPDATE @ 18:30 – It has been confirmed that emergency teams are attending to 2 injured parties, 1 of which is trapped inside a vehicle.
Whippingham Road has been closed in both directions.
UPDATE @ 19:24 – The Hampshire and Isle of Wight Air Ambulance has landed at Whippingham, where specialist doctors and paramedics are now treating a seriously injured individual.
Island Echo understands that 1 vehicle has left the carriageway and come to a stop in a hedge.
Whippingham Road is expected to remain closed for several hours.
UPDATE @ 19:50 – Isle of Wight Fire and Rescue Service have confirmed that 3 vehicles have been involved in the crash, with 1 person extricated by firefighters using cutting equipment.
The air ambulance is preparing to airlift the casualty to Southampton Hospital.
A second casualty has been taken to St Mary’s Hospital by land ambulance.
UPDATE @ 20:30 – Whippingham Road remains closed in both directions tonight, but is expected to re-open in the next 90 minutes or so.
Justin Harden of the Isle of Wight Fire and Rescue Service has confirmed that 2 pumping appliances and a rescue tender have responded to the crash, with crews using hydraulic cutting equipment to carry out a partial roof removal to extricate the trapped female driver.
It is understood the 3 vehicles involved are a VW Golf, a Dacia and a Renault Clio – but the impact has left at least 1 vehicle unrecognisable.
UPDATE @ 22:35 – Whippingham Road has now re-opened to all traffic following recovery of the vehicles.
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