Several police units alongside colleagues from the Hampshire & Isle of Wight Fire and Rescue service and the Isle of Wight Ambulance Service are in attendance on Sandown Road.
A paramedic officer is also at the scene.
Hard road closures are being introduced, with traffic being turned around and diverted through other routes.
The road towards Bembridge is closed between the junction with Hillway Road and the roundabout with Mill Road and Steyne Road.
UPDATE @ 16:31 – Firefighters from Ryde have stabilised the 5-door hatchback and are in the process of extricating the casualty.
To do this, the crews are using cutting equipment to remove the vehicles doors – providing enhanced access to the patient for paramedics.
A second ambulance has now arrived on the scene and the Hampshire and Isle of Wight Air Ambulance is also enroute, with the aircraft expected to land at a nearby field.
UPDATE @ 16:50 – The HIOWAA has landed in a field to the side of the scene, where firefighters are extricating the casualty.
Its thought that 2 vehicles have collided, with 1 taking a severe impact to the front end. 6 people are said to have been injured in the collision.
Specialist flying doctors are assessing and tending to the injured, indicating the potential severity of their injuries.
UPDATE @ 17:48 – Emergency services have now stood down from the scene, although police units remain to enforce the current and ongoing road closure.
Several of the 6 people involved have been treated for injuries ranging from minor to more serious, although despite the attendance of the Hampshire and Isle of Wight Air Ambulance, it is not thought that anyone has been airlifted.
2 vehicles – a silver Peugeot and a black Seat -have been severely damaged in the collision, and remain in situ at the crash site.
The road closure is expected to be in force for some time.
UPDATE: The road has now reopened.