Two pumping appliances from the Isle of Wight Fire and Rescue Service, several Police units and paramedics from the Isle of Wight Ambulance Service, including an ambulance officer, are currently attending the incident on Combley Road near to the Isle of Wight Steam Railway.
The road is closed in both directions and motorists are advised to find an alternative route.
Emergency crews were called to the scene at around 09:50, as reported first by Island Echo.
The incident has taken place on a notoriously tight corner, the same location emergency services were called to earlier this year when a Biffa lorry was involved in a similar incident.
The road has been closed just off Briddlesford Road and at the Isle of Wight Steam Railway.
UPDATE @ 10:55 – One person has been freed from the wreckage of their vehicle and transferred into the care of the Isle of Wight Ambulance Service.
The ambulance has left the scene and is conveying the casualty, a female, to St Mary’s Hospital, Newport. A second person, a male, has also been taken to hospital however neither injury are believed to be life-threatening.
Fire crews from Ryde are in the process of clearing a diesel spill on the carriageway as a result of the crash.
The road has now reopened in both directions following a two-hour closure.