Emergency services are on scene and traffic is building as a result of the incident, which occurred at just before 16:30.
The Isle of Wight Fire and Rescue Service are said to be responding to the incident.
UPDATE @ 16:56 – Police have closed The Downs between the Hare and Hounds pub at Downend and the junction with Lime Kiln Shute near Newchurch.
A yellow Kia Picanto has come off the carriageway and has rolled onto its roof in a field. It appears to have been travelling towards Ryde.
No one is trapped inside the vehicle, but firefighters from Newport are assisting paramedics with moving at least 2 individuals to the awaiting ambulance.
No other vehicles are thought to be involved.
UPDATE @ 17:05 – An elderly male and female – and a third individual – are now in the care of the Isle of Wight Ambulance Service. Thankfully, their injuries are not serious and they are being described as walking wounded. They are expected to be conveyed to St Mary’s Hospital as a precautionary measure.
The road remains closed at this time but is not likely to be closed for an extended period.
Traffic on the main Newport to Sandown road is backed up from the airport to Hale Common, according to reports.
UPDATE – The road has now re-opened.