A red Ford Fiesta and a silver Vauxhall Vectra have been involved in a shunt on Great Preston Road at the junction with High Park Road.
The driver of the Fiesta is medically trapped inside the vehicle.
Fire crews from Ryde and Newport are on scene alongside a fire officer, local Police and an ambulance crew.
The road has been closed in both directions with Southern Vectis buses diverting locally as a result.
UPDATE @ 12:15 – Fire crews have now removed the roof of the Fiesta and are working alongside paramedics to extricate the driver.
UPDATE @ 12:40 – The male casualty is now in the care of paramedics. He is to be conveyed to St Mary’s Hospital for further checks and treatment. His injuries are not life-threatening.
Emergency crews are preparing to start standing down from the incident, but the road is expected to remain closed until the Fiesta has been recovered.
The Vectra has been driven away from the scene by its owner.