A Suzuki Jimny has overturned and come to a rest on its side just outside the village of Niton this lunchtime (Friday).
Police and the Isle of Wight Ambulance Service were alerted to the crash on Newport Road, near to Kingates Lane, shortly before 12:50.
The road has been closed in both directions as emergency services deal with the incident and arrange recovery.
No one is thought to have been seriously injured in the single-vehicle incident.
Motorists are diverting locally.
Meanwhile, Police are currently dealing with a 2-car road traffic collision on Whitehouse Road near Porchfield.