Firefighters from Newport, Sandown and Shanklin are currently on scene at Winford Road alongside the Isle of Wight Ambulance Service, which has 1 Ambulance and a duty officer in attendance.
The crash has happened between the junctions of Watery Lane and Harbour Lake Road on a section of road recently made 30mph.
Debris has been throw across the carriageway as a result of a car crashing into a tree, causing significant damage to the vehicle.
The driver, who is out of the car, is currently being assessed at the scene by paramedics and specialist doctors from the air ambulance team.
Police have closed the road in both directions but a local diversion via Harbour Lake Road is possible.
The incident occurred at just before 20:10. No other vehicles are thought to be involved.
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