Multiple emergency service vehicles are reported to be responding to the scene on lights and sirens.
Fire control say they have mobilised appliances – believed to be 3 from Newport and Cowes – to the scene at Park Road.
The Isle of Wight Ambulance Service have also mobilised a number of resources.
Island Echo understands the incident has occurred at the junctions of Reynolds Close and Brooklands Road.
Southern Vectis say that their Route 1 buses via Roundhouse will be diverting from Three Gates Road via Newport Road and Victoria Road in both directions.
UPDATE @ 18:13 – 1 vehicle – a BMW – has rolled onto its side opposite Reynolds Close.
2 other cars have also been involved in the crash – a VW UP and a Mini One.
Firefighters are continuing to work to free the occupant of the rolled vehicle more than an hour after arriving on scene. Crews have stabilised the vehicle and are using cutting equipment to enable better access to the casualty.
2 fire appliances from Newport and 1 from Cowes are on scene alongside 2 Ambulances, an Ambulance Rapid Response Vehicle and an Ambulance Officer.
The road has been closed in both directions while emergency services deal with the incident.
UPDATE @ 18:53 – The casualty has now been removed from the vehicle and transferred into the care of the Isle of Wight Ambulance Service for onward conveyance to St Mary’s Hospital.
Crews are making up and hot debriefing before handing the scene over to Police for recovery.
UPDATE @ 19:15 – The Isle of Wight Fire and Rescue Service are now standing down from the incident.
Recovery of the BMW has been arranged and the road is expected to re-open once complete.