The incident has occurred between East Ashey Lane and the turning for Brading Downs on a winding section of carriageway.
A VW convertible and a motorcycle of unknown make have been involved in the smash, but neither the motorcyclist nor the car driver are thought to have sustained serious injuries.
The incident occurred at just before 10:25.
The road is blocked in both directions and is likely to remain closed for the next hour or 2.
UPDATE @ 10:40 – The Isle of Wight Ambulance Service are now on scene with 1 ambulance and a paramedic officer.
1 fire appliance from Ryde is also in attendance in the interests of scene safety due to a spillage.
UPDATE @ 11:11 – The road remains closed as the casualties are tended to and the debris is cleared.
The Isle of Wight Fire and Rescue Service has now stood down.
UPDATE @ 11:32 – 1 person – believed to be the motorcyclist – is now in the care of the Isle of Wight Ambulance Service.
A spokesperson for Hampshire Constabulary has said:
“We were called at 10.27am today, (28 July), to reports of a collision on Ashey Road, Ryde, between a Volkswagen Golf and a Honda motorcycle.
“Minor injuries were reported.”