Emergency services were called to Newport Road, close to Somerton Roundabout, shortly before 03:30 this morning (Saturday).
Island Echo understands a black Audi collided head-on into a tree at the side of the carriageway, resulting in debris being scattered across the road.
Multiple appliances from the Isle of Wight Fire and Rescue Service were mobilised to the scene alongside paramedics from the Isle of Wight Ambulance Service.
The road was under a hard closure for several hours but has now been re-opened by Island Roads following clearance of the wreckage and an oil spillage.
UPDATE @ 09:40 – It has been confirmed that 3 people were injured in the single vehicle collision, which happened at just gone 03:00.
1 person sustained serious, but not life-threatening injures in the incident, with 2 others sustaining minor injuries.
All 3 were conveyed to St Mary’s Hospital for treatment.
The Audi is said to have left the road and crashed into the tree after coming around the roundabout – from the Newport direction.
The investigation into the circumstances on the incident is ongoing. No arrests have been made.