The road has been closed in both directions as a result of the incident outside Tapnell Farm on the outskirts of Freshwater.
Multiple emergency vehicles have been seen responding to the scene of the crash, which occurred at around 08:30.
Motorists should avoid the area, diverting via Yarmouth Road or Military Road.
UPDATE @ 09:10 – The Isle of Wight Fire and Rescue Service have confirmed that they are attending a 2 car road traffic collision at Tapnell.
Fire crews from Newport and Freshwater are working to free persons trapped inside at least 1 of the vehicles.
UPDATE @ 09:44 – Firefighters have successfully extricated 1 female adult from a Renault Clio, which was involved in a front-end collision with a Mazda.
The casualty has been passed into the care of the Isle of Wight Ambulance Service, alongside a second female adult casualty. Both have been conveyed to St Mary’s Hospital.
Thankfully, no one has sustained any life-threatening injuries.
Middle Road is expected to re-open shortly.