The incident has occurred between Compton and Freshwater Bay at Hanover Point, resulting in the closure of the road.
Paramedics from the Isle of Wight Ambulance Service are on scene having been called to the incident shortly before 16:30.
Police are also in attendance, as are the Isle of Wight Fire and Rescue Service with 1 appliance from Newport and a Co-Responder from Freshwater.
The Needles Coastguard Rescue Team have stopped to offer assistance whilst returning to station from an earlier incident at Brook.
UPDATE @ 16:55 – Southern Vectis say their Route 12 bus is currently unable to serve Military Road and is therefore diverting via Middle Road and Chessell to reach Brook Triangle.
UPDATE @ 17:42 – The male rider of the motorcycle has been conveyed to St Mary’s Hospital by ambulance.
His injuries are not thought to be life-threatening.
The occupants of a Fiat Ducato have escaped injury.