Police have closed Cross Street, between George Street and Union Street, whilst colleagues from the Isle of Wight Fire and Rescue Service work to make entry into a flat above a dentist surgery.
Paramedics from the Isle of Wight Ambulance Service are on scene and are thought to have requested the assistance of fire crews shortly before 08:30.
An extension ladder has been used to reach a second floor window with crews also making their way to the flat internally via a staircase.
A number of tools are being utilised.
The road remains closed with all traffic being diverted locally, including Southern Vectis buses.
UPDATE @ 09:40 – Cross Street has now re-opened but emergency services remain on scene.
UPDATE @ 11:00 – It has been confirmed that the incident was prompted by a woman who raised concerns for the welfare of her friend, who lives alone. However, the individual did not require hospitalisation.