The crash has occurred at the junction with Highwood Lane and has involved 2 vehicles – a grey Mercedes estate and a small silver hatchback.
Traffic is being diverted locally by Police.
Southern Vectis say their buses will be diverting via Merstone in both directions until further notice.
UPDATE @ 12:58 – The Isle of Wight Fire and Rescue Service are working alongside paramedics to extricate 1 person from a silver hatchback car.
A second ambulance crew are checking over another casualty.
2 ambulances, an ambulance officer, 2 fire engines and several Police units are all in attendance.
All traffic is being diverted via Highwood Lane.
UPDATE @ 13:15 – The Isle of Wight Ambulance Service is conveying at least 2 people – 1 immobilised on a stretcher – to St Mary’s Hospital.
Resources are now starting to stand down from the incident and recovery of the 2 vehicles has been arranged.
UPDATE @ 15:25 – The road has now re-opened in both directions.