A van and car have collided at the junction of Green Lane and the High Street in Brading.
A Ford Transit and a Toyota Corolla have both suffered serious front end damage after coming together on the roundabout entering the town.
Emergency services are currently in attendance.
It is believed one woman has complained of back pain and is currently being transferred to a spinal board as a precautionary measure.
Police are directing traffic in the area with some delays to be expected.