Emergency services were called to the incident near the junction with Morton Old Road at around 08:30.
2 fire appliances from Ryde and Shanklin, a rescue tender from Newport and a duty officer are all currently in attendance alongside a rapid response paramedic and Police.
1 other person has been injured in the incident but is described as ‘walking wounded’. They are being placed on a spinal board.
The main through road has been closed in both directions. As a result, Southern Vectis buses Routes 2 and 3 will divert via Yaverland until further notice.
Motorists are urged to find an alternative route.
UPDATE @ 09:55 – Morton Road has now reopened in both directions.
2 people have been conveyed to St Mary’s Hospital by ambulance.