Multiple Police units responded to the incident near to Nunwell House at just before 22:10, where it is understood at least two vehicles have been involved in a crash on a long left hand bend.
Isle of Wight Ambulance Service paramedics have responded to the crash, however no one is believed to have been seriously injured.
Bartletts Service Station are on the scene to recover the vehicles involved.
The road remains closed in both directions.
UPDATE – The road has now reopened in both directions following the recovery of the vehicles.