Fire crews from Bembridge and Ryde were called to the scene shortly before 19:25 following reports of one vehicle having been involved in a road traffic collision.
A white Nissan Serena has come to rest on its side at the bottom of Hillway Road near to the junction with Sandown Road opposite Bembridge Airport.
One person has been conveyed to hospital by the Isle of Wight Ambulance Service, who deployed one ambulance and an ambulance officer to the incident. The casualties injuries are not thought to be life-threatening.
The Isle of Wight Fire and Rescue Service have now left the scene, however Police remain in attendance.
The road has been closed in both directions, with Southern Vectis Route 8 buses diverting via Bembridge Airport until further notice.
UPDATE @ 20:51 – Hillway Road, Bembridge has now reopened in both directions. Southern Vectis buses will resume a normal route.