Two appliances from the Isle of Wight Fire and Rescue Service are attending Mill Hill Road alongside paramedics from the Isle of Wight Ambulance Service.
One person is reported to be trapped inside their vehicle – a black Ford Focus Mk1 – with suspected spinal injuries. The incident has taken place at the junction with Victoria Road.
Emergency crews were called to the scene at just before 12:20.
UPDATE @ 12:59 – One person has been cut free from the wreckage by fire crews.
The road remains closed in both directions.
UPDATE @ 14:35 – The incident has been cleared and the road has reopened.
Photograph thanks to Kieron Paddock